Tell us where current kidney diagnostics falls short.

Cardiologist / diabetologist with renal interest

Kidney failure risk equations (e.g. KFRE)

None, I do not routinely assess tubular function

Non-invasive / suitable for routine clinical use

Uses a standard urine sample, no special collection required

Adds predictive value beyond eGFR and uACR

Predicts treatment response to kidney-protective medications (e.g. GLP-1 RA, SGLT2i, nsMRA)

Grounded in established renal (patho)physiology

Chronic kidney disease (CKD) progression monitoring

Early diagnosis of Acute kidney injury (AKI)

Early detection of nephrotoxicity (e.g. drug-induced)

Predicting need for renal replacement therapy

ADPKD (autosomal dominant polycystic kidney disease)

Prospective clinical validation in a large cohort

Demonstrated prediction of hard clinical outcomes (e.g. dialysis, cardiovascular events)

Demonstrated additive predictive value beyond eGFR and uACR

Head-to-head comparison with other markers in development (e.g. KIM-1, NGAL, Dickkopf-3, TNFR1/TNFR2, etc.)

Health economic analysis / cost-effectiveness data

Solid mechanistic basis grounded in established renal (patho)physiology